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Timed Up and Go Does Not Predict Falls in CMT1A: Why a Multidimensional Fall Risk Assessment Matters

Falls are common in Charcot–Marie–Tooth disease type 1A (CMT1A), and clinicians often rely on quick screening tools like the Timed Up and Go (TUG). The underlying assumption is straightforward: slower performance implies higher fall risk. This prospective study challenges that assumption. Over one year of follow-up, TUG time at baseline did not distinguish fallers from non-fallers, even when falls were categorized by frequency. Instead, the signals of risk appeared elsewhere—particularly in measures linked to postural instability and sarcopenia risk, reinforcing that fall risk in hereditary neuropathies is multifactorial and not captured by a single mobility test.

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